Transmitter release deficits at the neuromuscular synapse of mice with mutations in the Cav2.1 (alpha1A) subunit of the P/Q-type Ca2+ channel

Ann N Y Acad Sci. 2003 Sep:998:29-32. doi: 10.1196/annals.1254.005.

Authors

J J Plomp¹, A M van den Maagdenberg, M D Ferrari, R R Frants, P C Molenaar

Affiliation

¹ Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands. [email protected]

PMID: 14592860
DOI: 10.1196/annals.1254.005

No abstract available

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Acetylcholine / analysis
Animals
Calcium Channel Blockers / pharmacology
Calcium Channels, N-Type / genetics*
Calcium Channels, N-Type / metabolism
Diaphragm / drug effects
Diaphragm / metabolism
Diaphragm / physiopathology
Electric Stimulation
Electrophysiology
Excitatory Postsynaptic Potentials / drug effects
Excitatory Postsynaptic Potentials / physiology
In Vitro Techniques
Mice
Mice, Neurologic Mutants
Mutation*
Neuromuscular Junction / drug effects
Neuromuscular Junction / metabolism*
Neurotransmitter Agents / deficiency
Neurotransmitter Agents / genetics
Neurotransmitter Agents / metabolism*
Species Specificity
omega-Agatoxin IVA / pharmacology

Substances

Calcium Channel Blockers
Calcium Channels, N-Type
Neurotransmitter Agents
omega-Agatoxin IVA
voltage-dependent calcium channel (P-Q type)
Acetylcholine