[Central nervous system involvement by histoplasmosis as the unique manifestation of this disease in immunocompetent patients: presentation of two cases]

Arq Neuropsiquiatr. 2003 Sep;61(3B):859-63. doi: 10.1590/s0004-282x2003000500029. Epub 2003 Oct 28.
[Article in Portuguese]

Abstract

We present two patients with central nervous system involvement as the unique clinical manifestation of histoplasmosis. A clinical review confirmed the infrequency of this form of the disease, overall in childhood, being one of these cases the youngest in Brazilian reports. Comments about the diversity of clinical presentation and main differential diagnosis are presented. We analyze the serologic and cerebrospinal fluid results and, finally, discuss the drugs and duration of treatment.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Adult
  • Antifungal Agents / therapeutic use
  • Central Nervous System Fungal Infections / cerebrospinal fluid
  • Central Nervous System Fungal Infections / drug therapy
  • Central Nervous System Fungal Infections / microbiology*
  • Child
  • Female
  • Fluconazole / therapeutic use
  • Histoplasmosis / cerebrospinal fluid
  • Histoplasmosis / complications*
  • Histoplasmosis / drug therapy
  • Humans
  • Magnetic Resonance Imaging
  • Male

Substances

  • Antifungal Agents
  • Fluconazole