External beam radiation therapy to prevent anastomotic intimal hyperplasia in prosthetic arteriovenous fistulas: results of a randomized trial

Robert B van Tongeren; Peter C Levendag; Veronique L Coen; Paul I Schmitz; Frank M Gescher; Rene M Vernhout; Cees H Wittens; Cornelis M Bruijninckx

doi:10.1016/s0167-8140(03)00233-0

External beam radiation therapy to prevent anastomotic intimal hyperplasia in prosthetic arteriovenous fistulas: results of a randomized trial

Radiother Oncol. 2003 Oct;69(1):73-7. doi: 10.1016/s0167-8140(03)00233-0.

Authors

Robert B van Tongeren¹, Peter C Levendag, Veronique L Coen, Paul I Schmitz, Frank M Gescher, Rene M Vernhout, Cees H Wittens, Cornelis M Bruijninckx

Affiliation

¹ Department of Surgery, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.

PMID: 14597359
DOI: 10.1016/s0167-8140(03)00233-0

Abstract

External beam irradiation has a documented effect on intimal hyperplasia reduction. However, it did not result in less reinterventions or stenoses after radiation treatment of the venous anastomosis in polytetrafluoroethylene dialysis access.

Publication types

Clinical Trial
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Aged, 80 and over
Arteriovenous Shunt, Surgical*
Blood Flow Velocity
Blood Vessel Prosthesis*
Brachial Artery / radiation effects
Brachial Artery / surgery
Brachiocephalic Veins / radiation effects
Brachiocephalic Veins / surgery
Constriction, Pathologic / prevention & control
Female
Forearm / blood supply
Graft Occlusion, Vascular / prevention & control*
Graft Survival / radiation effects
Humans
Hyperplasia
Male
Middle Aged
Polytetrafluoroethylene
Prospective Studies
Radiotherapy Dosage
Renal Dialysis*
Tunica Intima / pathology
Tunica Intima / radiation effects*
Ultrasonography, Doppler, Duplex

Substances

Polytetrafluoroethylene