Neuroreceptor imaging with SPECT

J Clin Psychiatry. 1992 Nov:53 Suppl:29-34.

Abstract

Single photon emission computed tomography (SPECT) imaging can provide useful measurements of brain receptors and endogenous neurotransmitters and may have significant experimental and clinical applications. This presentation reviews the use of SPECT for neuroreceptor imaging. Studies of receptors for benzodiazepines, dopamine D2 agents, and dopamine reuptake sites will be used to exemplify the capabilities of SPECT. Tracers labeled with the radioisotope 125I have high affinity, high brain uptake, and high ratios of specific to nonspecific binding. Imaging studies of human and nonhuman primate brain will be presented, and the potential clinical applicability of these agents will be discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Humans
  • Iodine Radioisotopes
  • Magnetic Resonance Imaging
  • Mental Disorders / diagnosis
  • Mental Disorders / diagnostic imaging
  • Mental Disorders / physiopathology
  • Receptors, Dopamine / physiology
  • Sensory Receptor Cells / diagnostic imaging*
  • Tomography, Emission-Computed, Single-Photon* / instrumentation
  • Tomography, Emission-Computed, Single-Photon* / methods

Substances

  • Iodine Radioisotopes
  • Receptors, Dopamine