Measurement of skeletal muscle mass in Duchenne muscular dystrophy: use of 24-h creatinine excretion

Acta Diabetol. 2003 Oct:40 Suppl 1:S290-2. doi: 10.1007/s00592-003-0089-8.

Abstract

Creatinine concentration in 24-h urine has been proposed as an indirect measure of body skeletal muscle mass (SMM). We attempted to correlate urinary creatinine levels with SMM in eight patients with Duchenne muscular dystrophy, a progressive disease in which the degree of muscle wasting parallels the rate of progression. Magnetic resonance imaging and a newly developed protocol for image analysis were used for the measurement of SMM. The patients ate a creatine-free diet for the week before urine collection. Creatinine was measured with an enzymatic-colorimetric method. Mean (+/-SD) SMM value was 5.4+/-2.5 kg and urine creatinine levels 205.8+/-96.4 mg/day. Daily urinary creatinine excretion did not correlate with SMM. The simple creatinine determination in urine cannot predict SMM in Duchenne muscular dystrophy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers / urine
  • Body Height
  • Body Weight
  • Child
  • Creatinine / urine*
  • Humans
  • Muscle, Skeletal / anatomy & histology*
  • Muscular Dystrophy, Duchenne / physiopathology*
  • Regression Analysis
  • Reproducibility of Results

Substances

  • Biomarkers
  • Creatinine