Pathogenesis of murine cytomegalovirus infection

Astrid Krmpotic; Ivan Bubic; Bojan Polic; Pero Lucin; Stipan Jonjic

doi:10.1016/j.micinf.2003.09.007

Pathogenesis of murine cytomegalovirus infection

Microbes Infect. 2003 Nov;5(13):1263-77. doi: 10.1016/j.micinf.2003.09.007.

Authors

Astrid Krmpotic¹, Ivan Bubic, Bojan Polic, Pero Lucin, Stipan Jonjic

Affiliation

¹ Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, B. Branchetta 20, 51000 Rijeka, Croatia. [email protected]

PMID: 14623023
DOI: 10.1016/j.micinf.2003.09.007

Abstract

Infection of mice with murine cytomegalovirus (MCMV) is an established model for studying human cytomegalovirus (HCMV) infection. Similarly to HCMV infection, pathological changes and disease manifestations during MCMV infection are mainly dependent on the immune status of the mouse host. This review focuses mainly on the pathogenesis of MCMV infection in immunocompetent and immunodeficient and/or immature mice and discusses the principles of immunosurveillance of infection and the mechanisms by which this virus evades immune control.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cytomegalovirus / isolation & purification
Cytomegalovirus / pathogenicity*
Cytomegalovirus / physiology
Cytomegalovirus Infections / etiology
Cytomegalovirus Infections / immunology*
Cytomegalovirus Infections / physiopathology
Disease Models, Animal
Humans