Current developments in SELDI affinity technology

Mass Spectrom Rev. 2004 Jan-Feb;23(1):34-44. doi: 10.1002/mas.10066.

Abstract

The overall history and recent advancements in Surface-Enhanced Laser Desorption/Ionization (SELDI) affinity technology is reviewed. A detailed account of SELDI technology, utilizing Immobilized-Metal Affinity surfaces, pseudo-specific chromatographic surfaces, and biospecific interactive surfaces, is presented with particular emphasis placed upon examination of fundamental characteristics as well as specific applications for each. Finally, a detailed review of the specific use of such affinity surfaces in fundamental aspects of clinical, process, and research proteomics activity is presented.

Publication types

  • Review

MeSH terms

  • Molecular Probe Techniques / trends
  • Molecular Probes / chemical synthesis
  • Molecular Probes / chemistry*
  • Protein Array Analysis / methods*
  • Protein Array Analysis / trends*
  • Proteins / analysis*
  • Proteins / chemistry*
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods*
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / trends*

Substances

  • Molecular Probes
  • Proteins