Motor coordination in mice with hotfoot, Lurcher, and double mutations of the Grid2 gene encoding the delta-2 excitatory amino acid receptor

Physiol Behav. 2003 Nov;80(2-3):333-9. doi: 10.1016/j.physbeh.2003.08.006.

Abstract

Grid2(ho/ho) is a loss of function gene mutation resulting in abnormal dendritic arborizations of Purkinje cells. These mutants were compared in a series of motor coordination tests requiring balance and equilibrium to nonataxic controls (Grid2(ho/+)) and to a double mutant (Grid2(ho/Lc)) with an inserted Lc mutation. The performance of Grid2(ho/ho) mutant mice was poorer than that of controls on stationary beam, coat hanger, unsteady platform, and rotorod tests. Grid2(ho/Lc) did not differ from Grid2(Lc/+) mice. However, the insertion of the Lc mutation in Grid2(ho/Lc) potentiated the deficits found in Grid2(ho/ho) in stationary beam, unsteady platform, and rotorod tests. These results indicate a deleterious effect of the Lc mutation on Grid2-deficient mice.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alleles
  • Animals
  • Behavior, Animal / physiology
  • Body Weight / genetics
  • Cerebral Cortex / anatomy & histology
  • Cerebral Cortex / metabolism
  • Mice
  • Mice, Inbred Strains
  • Mice, Knockout
  • Mice, Neurologic Mutants / abnormalities*
  • Mice, Neurologic Mutants / genetics
  • Mice, Neurologic Mutants / metabolism
  • Mutation*
  • Psychomotor Performance / physiology*
  • Reaction Time
  • Receptors, Glutamate / genetics
  • Receptors, Glutamate / physiology*
  • Walking / physiology

Substances

  • Receptors, Glutamate
  • glutamate receptor delta 2