Abstract
We have evaluated the efficacy of voriconazole (VRC) in a murine model of systemic infection by Scedosporium apiospermum. The survival of mice treated with VRC at 5, 20, or 40 mg/kg/day was greater than that of the control group (P< or =0.0009). VRC reduced the tissue burden in the spleen and brain (P<0.001 in both organs) in comparison with that of the control group.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antifungal Agents / therapeutic use*
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Brain / microbiology
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Colony Count, Microbial
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Kidney / microbiology
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Male
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Mice
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Mycoses / drug therapy*
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Mycoses / microbiology
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Neutropenia / complications*
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Neutropenia / microbiology
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Pyrimidines / therapeutic use*
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Scedosporium*
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Spleen / microbiology
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Survival Analysis
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Triazoles / therapeutic use*
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Voriconazole
Substances
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Antifungal Agents
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Pyrimidines
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Triazoles
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Voriconazole