Abstract
beta-Alanine derivative 2 (IC(50)=16 nM) and related compounds were found to be potent MC4R agonists.
MeSH terms
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Animals
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Binding Sites
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Dipeptides / chemical synthesis*
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Dipeptides / chemistry
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Dipeptides / pharmacokinetics
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Dipeptides / pharmacology*
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Drug Design
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Feeding Behavior / drug effects
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Humans
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Kinetics
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Models, Animal
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Models, Molecular
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Receptor, Melanocortin, Type 4 / agonists*
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Structure-Activity Relationship
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beta-Alanine / pharmacokinetics
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beta-Alanine / pharmacology*
Substances
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Dipeptides
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Receptor, Melanocortin, Type 4
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beta-Alanine