beta-alanine dipeptides as MC4R agonists

Bioorg Med Chem Lett. 2003 Dec 15;13(24):4341-4. doi: 10.1016/j.bmcl.2003.09.036.

Abstract

beta-Alanine derivative 2 (IC(50)=16 nM) and related compounds were found to be potent MC4R agonists.

MeSH terms

  • Animals
  • Binding Sites
  • Dipeptides / chemical synthesis*
  • Dipeptides / chemistry
  • Dipeptides / pharmacokinetics
  • Dipeptides / pharmacology*
  • Drug Design
  • Feeding Behavior / drug effects
  • Humans
  • Kinetics
  • Models, Animal
  • Models, Molecular
  • Receptor, Melanocortin, Type 4 / agonists*
  • Structure-Activity Relationship
  • beta-Alanine / pharmacokinetics
  • beta-Alanine / pharmacology*

Substances

  • Dipeptides
  • Receptor, Melanocortin, Type 4
  • beta-Alanine