Abstract
A novel non-vanilloid VR1 antagonist consisting of a new vanilloid equivalent exhibits excellent analgesic effects as well as highly potent antagonistic activities in both capsaicin single channel and calcium uptake assays. In addition, the structural requirement for the vanilloid equivalent of the potent VR1 antagonist has also been elucidated.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Analgesics / chemical synthesis*
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Analgesics / chemistry
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Analgesics / pharmacology
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Animals
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Capsaicin / analogs & derivatives*
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Capsaicin / chemical synthesis
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Capsaicin / chemistry
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Capsaicin / pharmacology
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Mice
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Models, Molecular
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Molecular Conformation
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Pain / prevention & control
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Receptors, Drug / antagonists & inhibitors*
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Structure-Activity Relationship
Substances
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Analgesics
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Receptors, Drug
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Capsaicin