Abstract
In addition to the known 6-bromo-hypaphorine (2) and plakohypaphorine-A (3), the methanol extract of the Mediterranean tunicate Aplidium conicum was shown to contain conicamin, a novel indole alkaloid having histamine-antagonistic activity which structure was determined to be 1 on the basis of the spectral data.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Guinea Pigs
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Histamine Antagonists / chemistry
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Histamine Antagonists / isolation & purification
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Histamine Antagonists / pharmacology*
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Ileum / drug effects
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Ileum / physiology
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Indole Alkaloids / chemistry
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Indole Alkaloids / isolation & purification
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Indole Alkaloids / pharmacology*
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Magnetic Resonance Spectroscopy
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Male
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Molecular Conformation
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Molecular Structure
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Muscle Contraction / drug effects
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Muscle, Smooth / drug effects
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Muscle, Smooth / physiology
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Urochordata / chemistry*
Substances
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Histamine Antagonists
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Indole Alkaloids
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conicamin