A novel HLA-A allele: A*0257

Tissue Antigens. 2004 Jan;63(1):85-7. doi: 10.1111/j.1399-0039.2004.00154.x.

Abstract

A novel human leucocyte antigen-A*02 (HLA-A*02) allele was detected by reference strand-mediated conformation analysis (RSCA) of a DNA sample from a Tarahumara individual. Direct sequencing of HLA-A locus polymerase chain reaction products identified a mutation in one of the alleles. Cloning and sequencing confirmed the presence of a new allele, A*0257 which differed from A*0206 by two nucleotides at positions 355 and 362, inducing changes in residues 95 and 97, respectively, within the peptide-binding site. Those changes suggest that allele A*0257 may have resulted from an intralocus recombination event.

MeSH terms

  • Alleles*
  • Base Sequence
  • HLA-A Antigens / genetics*
  • HLA-A Antigens / immunology
  • Humans
  • Molecular Sequence Data
  • Mutation*
  • Polymerase Chain Reaction
  • Sequence Analysis, DNA

Substances

  • HLA-A Antigens

Associated data

  • GENBANK/AJ457989