Objective: To investigate the effect of intravenous administration of monoantibody to P-selectin (PS1) on the lung-metastasis characteristic of highly lung metastatic adenoid cystic carcinoma cell strain (ACC-M).
Methods: 3HTdR labeled ACC-M cells were injected intravenously through tail vein after using monoantibody to P-selectin. A mice of each group were killed at 2 h, 6 h and 18 h after infusion, respectively. The relative radioactivity (CPM) in the lung and liver was detected.
Results: 3H-activity per gram in lung of mAb group was lower than in control group. There was significant difference between the two groups (P < 0.001). There was no difference between the two groups of liver tissues (P > 0.005).
Conclusions: The results of this study suggested that the highly lung metastasis characteristic of ACC-M may be partially inhibited by the use of monoantibody to the P-selectin.