Abstract
A total of 7,837 clinical isolates of Candida were tested against fluconazole, and 351 resistant (fluconazole MIC >/=64 micro g/ml) isolates were identified (4% of the total tested). All fluconazole-resistant isolates were inhibited by caspofungin at concentrations that can be exceeded by standard doses (MIC at which 90% of the isolates were inhibited, 1 micro g/ml; 99% of the MICs were </=2 micro g/ml).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antifungal Agents / pharmacology*
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Candida / drug effects*
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Candida / isolation & purification
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Candida albicans / drug effects
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Candida albicans / isolation & purification
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Candida glabrata / drug effects
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Candida glabrata / isolation & purification
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Caspofungin
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Drug Resistance, Microbial / physiology*
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Echinocandins
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Fluconazole / pharmacology*
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Humans
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Lipopeptides
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Microbial Sensitivity Tests
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Peptides / pharmacology*
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Peptides, Cyclic*
Substances
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Antifungal Agents
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Echinocandins
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Lipopeptides
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Peptides
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Peptides, Cyclic
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Fluconazole
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Caspofungin