Abstract
Multidrug-resistant tuberculosis is an increasing health problem worldwide, especially in developing countries. The PCR-UHG-Rif assay, which detects mutations within the rpoB gene associated with rifampin resistance, was evaluated for its ability and reliability to detect and identify drug-resistant Mycobacterium tuberculosis in a developing country where tuberculosis is highly endemic.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antitubercular Agents / pharmacology
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Antitubercular Agents / therapeutic use
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DNA-Directed RNA Polymerases / genetics
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Drug Resistance, Multiple / genetics*
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Humans
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Microbial Sensitivity Tests
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Mycobacterium tuberculosis / drug effects
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Mycobacterium tuberculosis / genetics*
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Mycobacterium tuberculosis / isolation & purification
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Peru
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Polymerase Chain Reaction / methods*
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Predictive Value of Tests
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Rifampin / pharmacology
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Rifampin / therapeutic use
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Sensitivity and Specificity
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Tuberculosis / drug therapy
Substances
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Antitubercular Agents
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DNA-Directed RNA Polymerases
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RNA polymerase beta subunit
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Rifampin