No replication of the association between the Nicastrin gene and familial early-onset Alzheimer's disease

Emmanuelle Cousin; Didier Hannequin; Sandrine Macé; Bruno Dubois; Sylvain Ricard; Emmanuelle Génin; Christophe Brun; Céline Chansac; Laurent Pradier; Thierry Frebourg; Alexis Brice; Dominique Campion; Jean-François Deleuze

doi:10.1016/s0304-3940(03)01105-4

No replication of the association between the Nicastrin gene and familial early-onset Alzheimer's disease

Neurosci Lett. 2003 Dec 19;353(2):153-5. doi: 10.1016/s0304-3940(03)01105-4.

Authors

Emmanuelle Cousin¹, Didier Hannequin, Sandrine Macé, Bruno Dubois, Sylvain Ricard, Emmanuelle Génin, Christophe Brun, Céline Chansac, Laurent Pradier, Thierry Frebourg, Alexis Brice, Dominique Campion, Jean-François Deleuze

Affiliation

¹ Aventis Pharma, Evry Genetics Center and Neurodegenerative disease group, Paris Research Center, 13 Quai Jules Guesde, 94400 Vitry-sur-Seine, France.

PMID: 14664923
DOI: 10.1016/s0304-3940(03)01105-4

Abstract

Polymorphisms in the Nicastrin (NCSTN) gene have recently been associated with familial early-onset Alzheimer's disease (AD). The authors genotyped four NCTSN polymorphisms in a large cohort of 489 AD cases (including 158 sporadic early-onset AD cases and 95 familial early-onset AD cases) and 386 controls but failed to replicate the association between NCSTN haplotype B and AD.

Publication types

Comparative Study

MeSH terms

Age of Onset
Aged
Alzheimer Disease / genetics*
Amyloid Precursor Protein Secretases
Apolipoprotein E4
Apolipoproteins E / genetics
France
Gene Frequency
Genotype
Haplotypes
Humans
Membrane Glycoproteins / genetics*
Middle Aged
Polymerase Chain Reaction
Polymorphism, Single Nucleotide

Substances

Apolipoprotein E4
Apolipoproteins E
Membrane Glycoproteins
nicastrin protein
Amyloid Precursor Protein Secretases