Abstract
In the past year, our understanding of the mechanisms that regulate isotype switching has significantly progressed. Activation of germ line transcription by isotype-specific cytokines is emerging as a crucial mechanism for increasing the accessibility of a particular switch region, and targeting switch recombination.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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B-Lymphocytes / immunology*
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Humans
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Immunoglobulin A / genetics
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Immunoglobulin A / immunology
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Immunoglobulin E / genetics
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Immunoglobulin E / immunology
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Immunoglobulin Isotypes / genetics*
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Immunoglobulin Switch Region*
Substances
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Immunoglobulin A
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Immunoglobulin Isotypes
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Immunoglobulin E