[Systemic treatment for hepatocellular carcinoma]

Zentralbl Chir. 2003 Nov;128(11):906-10. doi: 10.1055/s-2003-44797.
[Article in German]

Abstract

Hepatocellular carcinoma (HCC) is one of the most frequent malignancies worldwide. A variety of pharmacological strategies has been evaluated in the treatment of HCC: classical chemotherapy, tamoxifen, octreotide, thymostimulin, pravastatin, (131)I-lipiodol as well as transarterial chemoperfusion (TAC) and chemoembolisation (TACE). TACE monotherapy or TACE combined with pravastatin resulted in a survival benefit of selected HCC patients. New strategies such as immunotherapy, antiangiogenic agents or cyclooxygenase inhibitors are under clinical investigation and might play a role in future therapies for HCC. Efficient strategies for the primary prevention of HCC are available and promising concepts in the secondary prevention have been reported.

Publication types

  • Review

MeSH terms

  • Adjuvants, Immunologic / therapeutic use
  • Angiogenesis Inhibitors / therapeutic use
  • Animals
  • Antibiotics, Antineoplastic / therapeutic use
  • Anticholesteremic Agents / therapeutic use
  • Antineoplastic Agents, Hormonal / administration & dosage
  • Antineoplastic Agents, Hormonal / therapeutic use
  • Carcinoma, Hepatocellular / diagnosis
  • Carcinoma, Hepatocellular / drug therapy*
  • Carcinoma, Hepatocellular / mortality
  • Carcinoma, Hepatocellular / prevention & control
  • Chemoembolization, Therapeutic
  • Cyclohexanes
  • Disease Models, Animal
  • Genetic Therapy
  • Humans
  • Immunotherapy
  • Liver Neoplasms / diagnosis
  • Liver Neoplasms / drug therapy*
  • Liver Neoplasms / mortality
  • Liver Neoplasms / prevention & control
  • Meta-Analysis as Topic
  • Mice
  • Multicenter Studies as Topic
  • O-(Chloroacetylcarbamoyl)fumagillol
  • Octreotide / therapeutic use
  • Pilot Projects
  • Pravastatin / therapeutic use
  • Primary Prevention
  • Prognosis
  • Randomized Controlled Trials as Topic
  • Risk Factors
  • Sesquiterpenes / therapeutic use
  • Tamoxifen / administration & dosage
  • Tamoxifen / therapeutic use
  • Thymus Extracts / therapeutic use
  • Time Factors

Substances

  • Adjuvants, Immunologic
  • Angiogenesis Inhibitors
  • Antibiotics, Antineoplastic
  • Anticholesteremic Agents
  • Antineoplastic Agents, Hormonal
  • Cyclohexanes
  • Sesquiterpenes
  • Thymus Extracts
  • thymostimulin
  • Tamoxifen
  • Pravastatin
  • Octreotide
  • O-(Chloroacetylcarbamoyl)fumagillol