Paroxysmal exercise-induced dystonia as a presenting feature of young-onset Parkinson's disease

Mov Disord. 2003 Dec;18(12):1545-7. doi: 10.1002/mds.10597.

Abstract

Paroxysmal exercise-induced dystonia (PED) is a rare, typically idiopathic familial condition, although sporadic and secondary cases have been reported. We present 2 cases where PED was the presenting feature of young-onset idiopathic Parkinson's disease (PD), preceding the onset of parkinsonian symptoms by 1.5 and 5 years, respectively. Initially, the dystonic symptoms occurred after prolonged exercise and were unilateral, affecting the foot in both patients. Over time, symptoms occurred with minimal exercise. We conclude that PED can rarely be the first and only feature of PD.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Age Factors
  • Antiparkinson Agents / therapeutic use
  • Basal Ganglia / metabolism
  • Diagnosis, Differential
  • Dopamine Plasma Membrane Transport Proteins
  • Dystonia / diagnosis*
  • Dystonia / drug therapy
  • Dystonia / etiology*
  • Exercise*
  • Facial Expression
  • Functional Laterality
  • Humans
  • Male
  • Membrane Glycoproteins*
  • Membrane Transport Proteins / deficiency
  • Middle Aged
  • Nerve Tissue Proteins*
  • Parkinson Disease / diagnosis*
  • Parkinson Disease / drug therapy
  • Putamen / metabolism
  • Tomography, Emission-Computed, Single-Photon
  • Tremor / diagnosis
  • Trihexyphenidyl / therapeutic use

Substances

  • Antiparkinson Agents
  • Dopamine Plasma Membrane Transport Proteins
  • Membrane Glycoproteins
  • Membrane Transport Proteins
  • Nerve Tissue Proteins
  • Trihexyphenidyl