Abstract
Eosinophil-associated gastrointestinal disorders (EGDs) are characterized by a pronounced cellular inflammation. Recent clinical and experimental investigations have implicated a family of molecules known as chemokines in the regulation of leukocyte recruitment in these diseases. The underlying cellular and molecular mechanisms involved in chemokine-mediated cellular infiltration are largely unknown. In this review, we describe the role of CD4+ T cells and eosinophils in the clinical manifestations of EGDs and discuss the current understanding of the role of chemokines in the recruitment of these cells in the expression of diseases.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Cell Movement / physiology
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Chemokines / immunology*
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Chemokines / metabolism
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Chemotactic Factors, Eosinophil / immunology*
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Chemotactic Factors, Eosinophil / physiology
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Eosinophilia / physiopathology*
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Gastrointestinal Diseases / immunology*
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Gastrointestinal Diseases / physiopathology
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Humans
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Immunity, Cellular / immunology
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Immunity, Cellular / physiology
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Inflammation Mediators / metabolism
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Risk Assessment
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Sensitivity and Specificity
Substances
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Chemokines
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Chemotactic Factors, Eosinophil
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Inflammation Mediators