Abstract
A peptide analogue from a histone H3 protein containing the L-fulleropyrrolidino-glutamic acid has been prepared by a solid-phase approach and has been fully characterized. By molecular modelling it was verified that this peptide derivative is able to retain a binding capacity to the MHC (major histocompatibility complex) molecule similar to that of the cognate epitope.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Chromatography, High Pressure Liquid
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Epitopes / chemistry
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Epitopes / immunology
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Fullerenes / chemistry*
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Glutamic Acid / chemistry
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Histones / chemistry*
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Models, Molecular
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Molecular Structure
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Peptides / chemical synthesis*
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Peptides / chemistry*
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Peptides / immunology
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Protein Structure, Tertiary
Substances
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Epitopes
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Fullerenes
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Histones
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Peptides
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Glutamic Acid