Relationships between serum IGF-1, IGFBP-2, interleukin-1beta and interleukin-6 in inflammatory bowel disease

Horm Res. 2004;61(4):159-64. doi: 10.1159/000075699. Epub 2003 Dec 22.

Abstract

Aims: To study the relationships between serum IGF-1, IGFBP-3 and IGFBP-2 and interleukin (IL)-1beta and IL-6 in inflammatory bowel disease (IBD).

Methods: Thirty-seven patients (18 males, 19 females, aged 8.8-26.1 years) with IBD (Crohn's disease, CD, n = 17, and ulcerative colitis, UC, n = 20) were studied. Patients were in relapse or remission according to established criteria. Serum IGF-1, IGFBP-3, IGFBP-2, IL-1beta and IL-6 levels were determined in patients and 15 healthy controls (aged 8.2-19.0 years).

Results: IGF-1 levels were lower in patients with CD in relapse compared with controls (p < 0.05). IGFBP-2 levels were higher in CD in relapse compared with other groups (all p < 0.05). In CD and UC patients (n = 37), IGF-1 levels were inversely correlated with the erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP). IGFBP-2 levels correlated positively with ESR and IL-1beta. IL-6 levels correlated positively with ESR and CRP. IL-1beta levels were elevated in CD in relapse compared to controls (p < 0.05) and were higher in UC in relapse than in other groups (all p < 0.05). In combined CD/UC patients in relapse (n = 20), IL-1beta levels were higher (p < 0.05) in patients with recto-sigmoiditis (n = 5) than in other patients.

Conclusions: IGF-1, IGFBP-2 levels were related to IL levels, disease activity and anatomical distribution, consistent with active inflammation modifying the IGF-IGFBP system, possibly relevant to disturbance of growth.

MeSH terms

  • Adolescent
  • Adult
  • Blood Sedimentation
  • C-Reactive Protein / metabolism
  • Case-Control Studies
  • Child
  • Colitis, Ulcerative / blood
  • Crohn Disease / blood
  • Female
  • Humans
  • Inflammatory Bowel Diseases / blood*
  • Insulin-Like Growth Factor Binding Protein 2 / blood*
  • Insulin-Like Growth Factor I / metabolism*
  • Interleukin-1 / blood*
  • Interleukin-6 / blood*
  • Male
  • Recurrence
  • Remission Induction

Substances

  • Insulin-Like Growth Factor Binding Protein 2
  • Interleukin-1
  • Interleukin-6
  • Insulin-Like Growth Factor I
  • C-Reactive Protein