Abstract
Postantibiotic effects (PAEs) of rifapentine, isoniazid, and moxifloxacin against Mycobacterium tuberculosis ATCC 27294 were studied using a radiometric culture system. Rifapentine at 20 mg/liter gave the longest PAE (104 h) among the drugs used alone. The combinations of rifapentine plus isoniazid, rifapentine plus moxifloxacin, and isoniazid plus moxifloxacin gave PAEs of 136.5, 59.0, and 8.3 h, respectively.
MeSH terms
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Anti-Infective Agents / pharmacology*
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Antitubercular Agents / pharmacology*
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Aza Compounds / pharmacology*
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Drug Combinations
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Fluoroquinolones
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Isoniazid / pharmacology*
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Microbial Sensitivity Tests
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Moxifloxacin
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Mycobacterium tuberculosis / drug effects*
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Mycobacterium tuberculosis / growth & development
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Quinolines / pharmacology*
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Rifampin / analogs & derivatives*
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Rifampin / pharmacology*
Substances
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Anti-Infective Agents
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Antitubercular Agents
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Aza Compounds
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Drug Combinations
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Fluoroquinolones
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Quinolines
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Moxifloxacin
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Isoniazid
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Rifampin
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rifapentine