The enemy at the gates. Ca2+ entry through TRPM7 channels and anoxic neuronal death

Cell. 2003 Dec 26;115(7):768-70. doi: 10.1016/s0092-8674(03)01019-5.

Abstract

In brain ischemia, gating of postsynaptic glutamate receptors is thought to initiate Ca2+ overload leading to excitotoxic neuronal death. In this issue, Aarts and colleagues describe a novel mechanism, whereby gating of TRPM7, a Ca2+-permeable nonselective cation channel, mediates Ca2+ overload and demise of anoxic neurons.

Publication types

  • News
  • Comment

MeSH terms

  • Animals
  • Calcium / metabolism*
  • Calcium Signaling / physiology
  • Cell Death
  • Humans
  • Hypoxia-Ischemia, Brain / metabolism*
  • Hypoxia-Ischemia, Brain / physiopathology
  • Ion Channel Gating / physiology
  • Ion Channels / metabolism*
  • Membrane Proteins*
  • Nerve Degeneration / metabolism*
  • Nerve Degeneration / physiopathology
  • Neurotoxins / antagonists & inhibitors
  • Neurotoxins / metabolism
  • Protein Kinases / metabolism*
  • Protein Serine-Threonine Kinases
  • TRPM Cation Channels

Substances

  • Ion Channels
  • Membrane Proteins
  • Neurotoxins
  • TRPM Cation Channels
  • Protein Kinases
  • Protein Serine-Threonine Kinases
  • TRPM7 protein, human
  • Calcium