Characterization of psu dic(6;5)(p21.3;q13) with reverse chromosome painting in a patient with secondary myelodysplastic syndrome following treatment for multiple myeloma

Lisa Lee-Jones; Bernard Ramsahoye; Margaret Booth; Peter Thompson; Jack Whittaker; Terry Hoy

doi:10.1016/s0165-4608(03)00218-8

Characterization of psu dic(6;5)(p21.3;q13) with reverse chromosome painting in a patient with secondary myelodysplastic syndrome following treatment for multiple myeloma

Cancer Genet Cytogenet. 2004 Jan 1;148(1):49-54. doi: 10.1016/s0165-4608(03)00218-8.

Authors

Lisa Lee-Jones¹, Bernard Ramsahoye, Margaret Booth, Peter Thompson, Jack Whittaker, Terry Hoy

Affiliation

¹ Tumour Molecular Genetics Group, Institute of Medical Genetics, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, Wales, UK. [email protected]

PMID: 14697641
DOI: 10.1016/s0165-4608(03)00218-8

Abstract

We report a case of a psu dic(6;5)(p21.3;q13) in a patient with secondary myelodysplastic syndrome (sMDS) following treatment for multiple myeloma. The abnormal chromosome was isolated by flow karyotyping and initially identified by reverse chromosome painting. The findings were then confirmed by forward painting. The value of flow karyotyping as a diagnostic technique in hematologic malignancies is discussed.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Chromosome Aberrations*
Chromosome Painting / methods*
Chromosomes, Human, Pair 5*
Chromosomes, Human, Pair 6*
Female
Humans
In Situ Hybridization, Fluorescence
Karyotyping
Middle Aged
Multiple Myeloma / complications
Multiple Myeloma / therapy*
Myelodysplastic Syndromes / genetics*