Discovery of novel PTP1b inhibitors

Denise A Ockey; Thomas R Gadek

doi:10.1016/j.bmcl.2003.10.058

Discovery of novel PTP1b inhibitors

Bioorg Med Chem Lett. 2004 Jan 19;14(2):389-91. doi: 10.1016/j.bmcl.2003.10.058.

Authors

Denise A Ockey¹, Thomas R Gadek

Affiliation

¹ Genentech, Inc., Department of Bioorganic Chemistry, One DNA Way, South San Francisco, CA 94080, USA. [email protected]

PMID: 14698165
DOI: 10.1016/j.bmcl.2003.10.058

Abstract

A small library of 19 compounds was designed based on unique structural features of PTP1b. Utilizing electrospray ionization mass spectrometry (ESI-MS) to provide binding information about complexes of enzyme and small molecule ligands, two classes of lead compounds were discovered.

MeSH terms

Enzyme Inhibitors / chemistry*
Enzyme Inhibitors / metabolism
Protein Tyrosine Phosphatase, Non-Receptor Type 1
Protein Tyrosine Phosphatases / antagonists & inhibitors*
Protein Tyrosine Phosphatases / metabolism
Spectrometry, Mass, Electrospray Ionization / methods

Substances

Enzyme Inhibitors
Protein Tyrosine Phosphatase, Non-Receptor Type 1
Protein Tyrosine Phosphatases