Abstract
Edunol (3), a pterocarpan isolated from Harpalyce brasiliana, a plant used in the northeast of Brazil against snakebites, was obtained by synthesis and showed antimyotoxic, antiproteolytic and PLA2 inhibitor properties. These proprieties could be improved through the synthesis of a bioisoster (5), where the prenyl group was replaced by the benzyl group.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Benzopyrans / chemistry
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Benzopyrans / isolation & purification
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Benzopyrans / pharmacology
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Bothrops*
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Chickens
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Creatine Kinase / metabolism
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Crotalid Venoms / administration & dosage
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Crotalid Venoms / antagonists & inhibitors*
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Crotalid Venoms / metabolism
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Dose-Response Relationship, Drug
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Drug Evaluation, Preclinical / methods
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In Vitro Techniques
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Injections, Intramuscular
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Mice
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Muscle, Skeletal / enzymology
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology
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Plant Roots
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Pterocarpans / chemistry*
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Pterocarpans / isolation & purification
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Pterocarpans / pharmacology*
Substances
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Benzopyrans
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Crotalid Venoms
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Plant Extracts
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Pterocarpans
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edunol
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Creatine Kinase