[Future perspectives. From basic research to the development of new therapies aimed at the inhibition of the different stages of signal transduction: applications in breast cancer]

Mario Campone; Pierre Kerbrat; Henri Roché; Jaffar Bennouna; Jean-Claude Cuillière; Bernard Le Mevel; Pierre Fumoleau

[Future perspectives. From basic research to the development of new therapies aimed at the inhibition of the different stages of signal transduction: applications in breast cancer]

Bull Cancer. 2003 Oct;90(10):851-64.

[Article in French]

Authors

Mario Campone¹, Pierre Kerbrat, Henri Roché, Jaffar Bennouna, Jean-Claude Cuillière, Bernard Le Mevel, Pierre Fumoleau

Affiliation

¹ CRLCC, Centre René-Gauducheau, bd Jacques-Monod, 44805 Saint-Herblain/Nantes. [email protected]

PMID: 14706914

Abstract

The mechanism implicated in the carcinogenesis are better understood and the transduction of signal is a potential target for new agents. In this review, we describe the different pathways implicated in the transduction of signal and the potential target for new agents in breast cancer.

Publication types

Review

MeSH terms

Antibodies, Monoclonal / therapeutic use
Antineoplastic Agents / therapeutic use*
Biomedical Research
Breast Neoplasms / drug therapy*
Breast Neoplasms / enzymology
Enzyme Inhibitors / therapeutic use*
Female
Humans
Protein Serine-Threonine Kinases / antagonists & inhibitors
Protein-Tyrosine Kinases / antagonists & inhibitors
Receptor Protein-Tyrosine Kinases / antagonists & inhibitors*
Receptor Protein-Tyrosine Kinases / physiology
Receptor, ErbB-2 / physiology
Second Messenger Systems
Signal Transduction / drug effects*
Signal Transduction / physiology

Substances

Antibodies, Monoclonal
Antineoplastic Agents
Enzyme Inhibitors
Protein-Tyrosine Kinases
Receptor Protein-Tyrosine Kinases
Receptor, ErbB-2
Protein Serine-Threonine Kinases