Abstract
We examined the effect of Helicobacter pylori (H. pylori) eradication on lipids and apolipoproteins in 87 patients with duodenal ulcers. A significant increase was observed in high-density lipoprotein (HDL) cholesterol (+24.7%, p <0.001), apolipoprotein AI (+9.0%, p <0.001), and apolipoprotein AII (+11.7%, p <0.001) after eradication. Minor increases occurred in total cholesterol, triglycerides, and apolipoprotein B, whereas low-density lipoprotein cholesterol remained unchanged. Our results suggest that chronic H. pylori infection reduces plasma levels of HDL cholesterol and that eradication improves the lipoprotein pattern.
Publication types
-
Clinical Trial
-
Multicenter Study
-
Randomized Controlled Trial
MeSH terms
-
Apolipoprotein A-I / blood
-
Apolipoprotein A-II / blood
-
Apolipoproteins B / blood
-
Cholesterol, HDL / blood*
-
Coronary Disease / epidemiology
-
Drug Therapy, Combination
-
Duodenal Ulcer / blood
-
Duodenal Ulcer / microbiology*
-
Female
-
Helicobacter Infections / blood
-
Helicobacter Infections / drug therapy*
-
Helicobacter pylori* / isolation & purification
-
Humans
-
Lipoproteins / blood*
-
Male
-
Middle Aged
-
Retrospective Studies
-
Risk
-
Triglycerides / blood
Substances
-
Apolipoprotein A-I
-
Apolipoprotein A-II
-
Apolipoproteins B
-
Cholesterol, HDL
-
Lipoproteins
-
Triglycerides