Abstract
The authors examined four- and six-loci haplotype constructs (from five single nucleotide polymorphisms and three microsatellite regions) of the alpha-synuclein gene in patients with Parkinson's disease (PD) and controls in an ethnic Chinese population. Logistic regression analysis demonstrated an association of NACP-Rep1 (p = 0.002) and L478 (p < 0.0001) with risk of PD after correction for the effects of age, sex, and the other polymorphic loci. Specific four-loci and six-loci haplotypes were significantly associated with an increased or decreased risk of PD.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Case-Control Studies
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China / ethnology
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Female
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Genetic Predisposition to Disease*
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Haplotypes*
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Humans
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Incidence
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Male
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Microsatellite Repeats / genetics
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Middle Aged
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Monte Carlo Method
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Nerve Tissue Proteins / genetics*
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Odds Ratio
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Parkinson Disease / epidemiology
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Parkinson Disease / genetics*
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Polymorphism, Genetic / genetics*
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Risk Assessment
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Singapore / epidemiology
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Synucleins
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alpha-Synuclein
Substances
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Nerve Tissue Proteins
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SNCA protein, human
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Synucleins
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alpha-Synuclein