Abstract
A fibronectin fragment, which spans from the ninth to tenth type III domain, showed > 95% biological activity in promoting osteoblast adhesion, proliferation and differentiation level compared with those of native fibronectin (FN) molecule. This suggests that the FN type III ninth-tenth domain fragment serves a good substitute for native FN in biomimetic application for osteogenesis.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Biomimetics / methods
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Cell Adhesion / drug effects
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Cell Adhesion / physiology
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Cell Differentiation / drug effects
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Cell Differentiation / physiology
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Cell Division / drug effects
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Cell Division / physiology
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Fibronectins / chemistry
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Fibronectins / metabolism*
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Fibronectins / pharmacology
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Gene Expression Regulation / physiology*
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Osteoblasts / cytology
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Osteoblasts / drug effects
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Osteoblasts / physiology*
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Osteogenesis / drug effects
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Osteogenesis / physiology*
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Peptide Fragments / chemistry
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Peptide Fragments / metabolism*
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Peptide Fragments / pharmacology
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Tissue Engineering / methods*
Substances
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Fibronectins
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Peptide Fragments