Abstract
Primary cardiac lymphoma (PCL), defined as a lymphoma clinically mimicking cardiac disease, with the bulk of the tumor located intrapericardially, is extremely rare in immunocompetent patients. Clinical manifestations vary depending on sites of involvement in the heart and include chest pain, arrhythmias, pericardial effusion, and heart failure. Diagnosis is often difficult and may require invasive procedures; in some cases, diagnosis is not made until autopsy. Histologically, nearly all cases of PCL reported thus far have been of B-cell origin. In this report, we describe a case of PCL of T-cell origin in an adult immunocompetent patient, the second reported in the literature to the best of our knowledge, and provide a brief overview of the features of previously published PCL cases.
MeSH terms
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Biomarkers, Tumor / blood
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Biopsy
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Bleomycin / administration & dosage
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Cyclophosphamide / administration & dosage
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Diagnostic Errors
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Doxorubicin / administration & dosage
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Dyspnea / etiology
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Fatal Outcome
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Female
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Heart Neoplasms / complications
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Heart Neoplasms / diagnosis
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Heart Neoplasms / drug therapy
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Heart Neoplasms / pathology*
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Humans
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Immunophenotyping
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L-Lactate Dehydrogenase / blood
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Leucovorin / administration & dosage
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Lymphoma, T-Cell / complications
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Lymphoma, T-Cell / diagnosis
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Lymphoma, T-Cell / drug therapy
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Lymphoma, T-Cell / pathology*
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Magnetic Resonance Imaging
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Methotrexate / administration & dosage
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Middle Aged
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Neoplasm Proteins / blood
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Neoplastic Stem Cells / chemistry
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Neoplastic Stem Cells / pathology
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Pericarditis / diagnosis
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Prednisone / administration & dosage
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T-Lymphocytes / chemistry
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T-Lymphocytes / pathology
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Tachycardia / etiology
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Thoracic Surgery, Video-Assisted
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Vincristine / administration & dosage
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Virus Diseases / diagnosis
Substances
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Biomarkers, Tumor
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Neoplasm Proteins
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Bleomycin
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Vincristine
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Doxorubicin
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Cyclophosphamide
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L-Lactate Dehydrogenase
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Leucovorin
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Prednisone
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Methotrexate