Benzo[a]pyrene phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than benzo[a]pyrene glucuronides in cell lines derived from the human aerodigestive tract

Carcinogenesis. 2004 May;25(5):793-9. doi: 10.1093/carcin/bgh078. Epub 2004 Jan 16.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aryl Hydrocarbon Hydroxylases / metabolism*
  • Benzo(a)pyrene / metabolism*
  • Carcinoma, Squamous Cell / metabolism
  • Carcinoma, Squamous Cell / pathology
  • Cell Line
  • Cyclooxygenase 2
  • Cytochrome P-450 CYP1A1 / metabolism*
  • Cytochrome P-450 CYP1B1
  • Glucuronides / metabolism*
  • Humans
  • Isoenzymes / metabolism*
  • Leukoplakia, Oral / metabolism
  • Leukoplakia, Oral / pathology*
  • Membrane Proteins
  • Mouth Mucosa / metabolism
  • Mouth Neoplasms / metabolism
  • Mouth Neoplasms / pathology
  • Phenols / metabolism
  • Prostaglandin-Endoperoxide Synthases / metabolism*
  • Tongue / metabolism
  • Tongue / pathology

Substances

  • Glucuronides
  • Isoenzymes
  • Membrane Proteins
  • Phenols
  • Benzo(a)pyrene
  • Aryl Hydrocarbon Hydroxylases
  • CYP1B1 protein, human
  • Cytochrome P-450 CYP1A1
  • Cytochrome P-450 CYP1B1
  • Cyclooxygenase 2
  • PTGS2 protein, human
  • Prostaglandin-Endoperoxide Synthases