Abstract
High-dose cyclophosphamide can be used to obtain haematological stem cells from the peripheral blood. In this paper we analyse the dynamics of appearance of cells with these characteristics, together with the impact of this drug on the immunological system. Cyclophosphamide seems to possess immunomodulating effects even at high doses.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Breast Neoplasms / blood
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Breast Neoplasms / drug therapy
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Breast Neoplasms / immunology
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Cyclophosphamide / administration & dosage
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Cyclophosphamide / pharmacology*
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Female
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Hematopoietic Stem Cells / drug effects
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Hematopoietic Stem Cells / physiology*
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Humans
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Immune System / drug effects
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Melphalan / administration & dosage
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Middle Aged
Substances
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Cyclophosphamide
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Melphalan