Immunomodulatory constituents from an Ascomycete, Chaetomium seminudum

J Nat Prod. 2004 Jan;67(1):98-102. doi: 10.1021/np0302201.

Abstract

A screening study focusing on immunomodulatory activity of the EtOAc extract of an Ascomycete, Chaetomium seminudum, has afforded a known epipolythiodioxopiperazine, chetomin (1), together with three new chetomin-related metabolites named chetoseminudins A (2), B (3), and C (4). Among these four metabolites, 1 and 2 have been deduced as the immunosuppressive features of this fungus.

MeSH terms

  • Adjuvants, Immunologic / chemistry
  • Adjuvants, Immunologic / isolation & purification*
  • Adjuvants, Immunologic / pharmacology
  • Animals
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology
  • Chaetomium / chemistry*
  • Disulfides
  • Heterocyclic Compounds, 4 or More Rings / chemistry
  • Heterocyclic Compounds, 4 or More Rings / isolation & purification*
  • Heterocyclic Compounds, 4 or More Rings / pharmacology
  • Indole Alkaloids
  • Japan
  • Lymphocytes / drug effects
  • Mice
  • Molecular Structure
  • Spleen / cytology

Substances

  • Adjuvants, Immunologic
  • Anti-Bacterial Agents
  • Disulfides
  • Heterocyclic Compounds, 4 or More Rings
  • Indole Alkaloids
  • chetoseminudin A
  • chetoseminudin B
  • chetoseminudin C
  • chetomin