Abstract
A screening study focusing on immunomodulatory activity of the EtOAc extract of an Ascomycete, Chaetomium seminudum, has afforded a known epipolythiodioxopiperazine, chetomin (1), together with three new chetomin-related metabolites named chetoseminudins A (2), B (3), and C (4). Among these four metabolites, 1 and 2 have been deduced as the immunosuppressive features of this fungus.
MeSH terms
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Adjuvants, Immunologic / chemistry
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Adjuvants, Immunologic / isolation & purification*
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Adjuvants, Immunologic / pharmacology
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Animals
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology
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Chaetomium / chemistry*
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Disulfides
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Heterocyclic Compounds, 4 or More Rings / chemistry
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Heterocyclic Compounds, 4 or More Rings / isolation & purification*
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Heterocyclic Compounds, 4 or More Rings / pharmacology
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Indole Alkaloids
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Japan
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Lymphocytes / drug effects
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Mice
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Molecular Structure
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Spleen / cytology
Substances
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Adjuvants, Immunologic
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Anti-Bacterial Agents
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Disulfides
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Heterocyclic Compounds, 4 or More Rings
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Indole Alkaloids
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chetoseminudin A
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chetoseminudin B
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chetoseminudin C
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chetomin