Plakolide A, a new gamma-lactone from the marine sponge Plakortis sp

Sarath P Gunasekera; Richard A Isbrucker; Ross E Longley; Amy E Wright; Shirley A Pomponi; John K Reed

doi:10.1021/np030294c

Plakolide A, a new gamma-lactone from the marine sponge Plakortis sp

J Nat Prod. 2004 Jan;67(1):110-1. doi: 10.1021/np030294c.

Authors

Sarath P Gunasekera¹, Richard A Isbrucker, Ross E Longley, Amy E Wright, Shirley A Pomponi, John K Reed

Affiliation

¹ Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 U.S. 1 North, Fort Pierce, FL 34946, USA. [email protected]

PMID: 14738400
DOI: 10.1021/np030294c

Abstract

Plakolide A (1), a new alpha-exomethylene-gamma-lactone isolated from the marine sponge Plakortis sp., was found to inhibit inducible nitric oxide synthase (iNOS) activity. The isolation, structure elucidation, and biological activity of plakolide A is described.

MeSH terms

Animals
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / isolation & purification*
Enzyme Inhibitors / pharmacology
Lactones / chemistry
Lactones / isolation & purification*
Lactones / pharmacology
Molecular Structure
Nitric Oxide Synthase / antagonists & inhibitors*
Nitric Oxide Synthase Type II
Porifera / chemistry*

Substances

Enzyme Inhibitors
Lactones
plakolide A
Nitric Oxide Synthase
Nitric Oxide Synthase Type II