Possible association between Cys311Ser polymorphism of paraoxonase 2 gene and late-onset Alzheimer's disease in Chinese

Jiajun Shi; Sizhong Zhang; Mouni Tang; Xiehe Liu; Tao Li; Haiying Han; Yingcheng Wang; Yangbo Guo; Jinghua Zhao; Hai Li; Cui Ma

doi:10.1016/j.molbrainres.2003.10.018

Possible association between Cys311Ser polymorphism of paraoxonase 2 gene and late-onset Alzheimer's disease in Chinese

Brain Res Mol Brain Res. 2004 Jan 5;120(2):201-4. doi: 10.1016/j.molbrainres.2003.10.018.

Authors

Jiajun Shi¹, Sizhong Zhang, Mouni Tang, Xiehe Liu, Tao Li, Haiying Han, Yingcheng Wang, Yangbo Guo, Jinghua Zhao, Hai Li, Cui Ma

Affiliation

¹ Key Laboratory of Biotherapy of Human Diseases, Department of Medical Genetics, West China Hospital and Division of Human Morbid Genomics, Ministry of Education, Sichuan University, Chengdu, 610041, China. [email protected]

PMID: 14741412
DOI: 10.1016/j.molbrainres.2003.10.018

Abstract

The common polymorphism at codon 311 (C311S) of paraoxonase 2 gene (PON2) was investigated in 165 patients with sporadic late-onset Alzheimer's disease (LOAD) and 174 controls in Chinese. The PON2*C allele frequency was significantly increased in the patients as compared with controls. However, no significant difference was observed after stratification of apolipoprotein E (ApoE) epsilon4 allele. These results suggested that the PON2 polymorphism might be a risk factor for LOAD independent of ApoE epsilon4 status in Chinese.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aged, 80 and over
Alleles
Alzheimer Disease / genetics*
Apolipoproteins E / genetics
Aryldialkylphosphatase / genetics*
Aryldialkylphosphatase / metabolism
Asian People / genetics*
Chi-Square Distribution
Cysteine / genetics
Female
Gene Frequency
Genetic Predisposition to Disease*
Genotype
Humans
Male
Polymerase Chain Reaction / methods
Polymorphism, Genetic*
Serine / genetics

Substances

Apolipoproteins E
Serine
Aryldialkylphosphatase
PON2 protein, human
Cysteine