Abstract
Resistance to carbapenems is an emerging problem among gram-negative hospital pathogens. A transferable plasmid encoding the VIM-4 metallo-beta-lactamase was detected in isolates of Klebsiella pneumoniae and Enterobacter cloacae obtained from a single patient under carbapenem therapy. Thus, enterobacteria appear to increasingly contribute to the spread of VIM-type enzymes.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Conjugation, Genetic / genetics*
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Enterobacter cloacae / drug effects
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Enterobacter cloacae / enzymology*
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Enterobacter cloacae / genetics*
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Enterobacteriaceae Infections / microbiology
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Female
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Humans
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Klebsiella Infections / microbiology
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Klebsiella pneumoniae / drug effects
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Klebsiella pneumoniae / enzymology*
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Klebsiella pneumoniae / genetics*
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Plasmids / genetics*
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Reverse Transcriptase Polymerase Chain Reaction
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beta-Lactamases / biosynthesis*
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beta-Lactamases / genetics*
Substances
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beta-Lactamases
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metallo-beta-lactamase VIM-4, Enterobacter cloacae
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metallo-beta-lactamase VIM-4, Klebsiella pneumoniae