Real-time measurement of in vitro flow by Fourier-domain color Doppler optical coherence tomography

Opt Lett. 2004 Jan 15;29(2):171-3. doi: 10.1364/ol.29.000171.

Abstract

The possibility of measuring a full Doppler flow depth profile in parallel by use of frequency-domain optical coherence tomography is demonstrated. The method is based on a local phase analysis of the backscattered signal and allows for imaging of bidirectional Doppler flow. The Doppler frequency limit is 5 kHz for the presented measurements and is set by half of the frame rate of the CCD detector array. We measured the flow of 0.3-microm microspheres suspended in distilled water at controlled flow rates and in vitro human blood flow through a 200-microm capillary with a real-time color-encoded Doppler tomogram rate of 2-3/s.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blood Cells / physiology
  • Blood Cells / radiation effects
  • Blood Vessels / physiology*
  • Computer Systems*
  • Fourier Analysis*
  • Humans
  • In Vitro Techniques
  • Microspheres
  • Models, Cardiovascular*
  • Regional Blood Flow
  • Rheology
  • Scattering, Radiation
  • Tomography, Optical Coherence*
  • Ultrasonography, Doppler, Color*