The large majority of liver tumors are metastatic, of which colorectal deposits are the most common. Resection is the preferable mode of treatment because it offers the possibility of prolonged survival, but this strategy is only viable in about 25% of patients. This is due to either the proximity of the disease to the portal structures or to the number of metastases. Other treatment options are therefore required for liver tumors, such as chemotherapy, radiofrequency ablation, laser photocoagulation, chemoembolization, and cryotherapy. This article focuses on cryotherapy as a method of treating unresectable hepatic tumors.