[A case of effective weekly paclitaxel administration for primary lesion of schirrous gastric cancer]

Gan To Kagaku Ryoho. 2004 Jan;31(1):91-3.
[Article in Japanese]

Abstract

We report a case of advanced schirrous gastric cancer with carcinomatous peritonitis. Chemotherapy with TS-1 was applied during the first 4 weeks, but the tumor did not respond to this therapy. Next, paclitaxel (TXL) was administered at a weekly dose of 90 mg/body/day for 3 weeks followed by a week interval of rest. Remarkable mass reduction of primary tumor was observed after 3 courses of treatment, and the symptom derived from primary tumor was relieved without significant side effects. The clinical course for schirrous gastric cancer with carcinomatous peritonitis is still miserable for patients, although many attempts have been made to improve its prognosis. A weekly paclitaxel regimen appears to be one of the promising treatment for schirrous gastric cancer.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Adenocarcinoma, Scirrhous / drug therapy*
  • Adenocarcinoma, Scirrhous / secondary
  • Aged
  • Antineoplastic Agents, Phytogenic / administration & dosage*
  • Drug Administration Schedule
  • Humans
  • Male
  • Paclitaxel / administration & dosage*
  • Peritoneal Neoplasms / secondary
  • Peritonitis / drug therapy*
  • Peritonitis / etiology
  • Stomach Neoplasms / drug therapy*
  • Stomach Neoplasms / pathology

Substances

  • Antineoplastic Agents, Phytogenic
  • Paclitaxel