Central arrhythmogenic effects of N-methyl-D-aspartate (NMDA) in anesthetized rats: influence of the denervation of the carotid-sinus baroreceptors on the susceptibility to arrhythmias

L Berrino; B Cuparencu; V de Novellis; L Stella; M Magrella; F Rossi

Central arrhythmogenic effects of N-methyl-D-aspartate (NMDA) in anesthetized rats: influence of the denervation of the carotid-sinus baroreceptors on the susceptibility to arrhythmias

Res Commun Chem Pathol Pharmacol. 1992 Nov;78(2):141-9.

Authors

L Berrino¹, B Cuparencu, V de Novellis, L Stella, M Magrella, F Rossi

Affiliation

¹ Institute of Pharmacology and Toxicology, First Faculty of Medicine and Surgery, University of Naples Federico II, Italy.

PMID: 1475526

Abstract

The intracerebroventricular (i.c.v.) administration of NMDA into urethane anesthetized rats could induce centrogenic cardiac arrhythmias. There were some important differences between sodium glutamate- and NMDA-induced arrhythmias which rendered it difficult to accept the assumption that glutamate-induced arrhythmias were due to the stimulation of only NMDA receptors. Denervation of the carotid-sinus baroreceptor zones enhanced the central arrhythmogenic activity of both sodium glutamate and NMDA.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anesthesia
Animals
Arrhythmias, Cardiac / chemically induced
Arrhythmias, Cardiac / physiopathology*
Brain / drug effects
Brain / physiopathology
Carotid Sinus / innervation*
Denervation
Disease Susceptibility
Electrocardiography
Female
Injections, Intraventricular
Male
N-Methylaspartate / administration & dosage
N-Methylaspartate / pharmacology*
Pressoreceptors / physiology*
Rats
Rats, Wistar
Sodium Glutamate / pharmacology
Urethane / administration & dosage

Substances

Urethane
N-Methylaspartate
Sodium Glutamate