Abstract
We treated Apc(min) mice, which are predisposed to intestinal polyposis, with a selective synthetic agonist of peroxisome proliferator-activated receptor-delta (PPAR-delta). Exposure of Apc(min) mice to the PPAR-delta ligand GW501516 resulted in a significant increase in the number and size of intestinal polyps. The most prominent effect was on polyp size; mice treated with the PPAR-delta activator had a fivefold increase in the number of polyps larger than 2 mm. Our results implicate PPAR-delta in the regulation of intestinal adenoma growth.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adenoma / metabolism
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Adenoma / pathology*
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Adenomatous Polyposis Coli Protein / metabolism
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Animals
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Cell Line, Tumor
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Dose-Response Relationship, Drug
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Genes, APC
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Humans
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Intestinal Neoplasms / metabolism
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Intestinal Neoplasms / pathology*
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Intestinal Polyps / metabolism
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Intestinal Polyps / pathology*
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Ligands
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Mice
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Receptors, Cytoplasmic and Nuclear / agonists*
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Receptors, Cytoplasmic and Nuclear / metabolism*
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Thiazoles / metabolism
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Thiazoles / pharmacology*
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Transcription Factors / agonists*
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Transcription Factors / metabolism*
Substances
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Adenomatous Polyposis Coli Protein
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GW 501516
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Ligands
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Receptors, Cytoplasmic and Nuclear
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Thiazoles
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Transcription Factors