Abstract
Bicarbonate-responsive "soluble" adenylyl cyclase resides, in part, inside the mammalian cell nucleus where it stimulates the activity of nuclear protein kinase A to phosphorylate the cAMP response element binding protein (CREB). The existence of this complete and functional, nuclear-localized cAMP pathway establishes that cAMP signals in intracellular microdomains and identifies an alternate pathway leading to CREB activation.
Copyright The Rockefeller University Press
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adenylyl Cyclase Inhibitors
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Adenylyl Cyclases / metabolism*
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Animals
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Bicarbonates / metabolism*
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Cell Line
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Cell Nucleus / enzymology*
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Chlorocebus aethiops
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Cyclic AMP / metabolism*
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Cyclic AMP Response Element-Binding Protein / metabolism
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Cyclic AMP-Dependent Protein Kinases / metabolism
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Enzyme Activation
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Gene Expression Regulation
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Hepatocytes / cytology
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Hepatocytes / metabolism
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Humans
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Immunohistochemistry
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Phosphorylation
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Rats
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Second Messenger Systems / physiology
Substances
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Adenylyl Cyclase Inhibitors
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Bicarbonates
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Cyclic AMP Response Element-Binding Protein
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Cyclic AMP
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Cyclic AMP-Dependent Protein Kinases
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Adenylyl Cyclases