Abstract
A newly synthetized aniline derivative series has been tested on histamine-stimulated gastric acid secretion in conscious cats and dogs and compared to the proton pump inhibitors omeprazole and NC 1300. The compounds markedly and long-lastingly inhibited acid output with a potency lower than omeprazole but very close to the reference compound NC 1300. The results show that the introduction of a nitrogen atom, irrespective of the position in the benzimidazole ring does not seem to influence the gastric antisecretory activity.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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2-Pyridinylmethylsulfinylbenzimidazoles
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Animals
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Benzimidazoles / pharmacology*
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Cats
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Consciousness
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Depression, Chemical
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Dogs
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Dose-Response Relationship, Drug
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Drug Administration Routes
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Duodenum / drug effects*
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Duodenum / metabolism
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Gastric Acid / metabolism*
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Gastric Mucosa / drug effects*
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Gastric Mucosa / metabolism
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Histamine / pharmacology
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Molecular Structure
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Omeprazole / pharmacology*
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Pepsin A / metabolism*
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Secretory Rate / drug effects
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Structure-Activity Relationship
Substances
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2-Pyridinylmethylsulfinylbenzimidazoles
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Benzimidazoles
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2-((2-dimethylaminobenzyl)sulfinyl)benzimidazole
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Histamine
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Pepsin A
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Omeprazole