Are we ready for universal influenza vaccination in paediatrics?

Lancet Infect Dis. 2004 Feb;4(2):75-83. doi: 10.1016/S1473-3099(04)00926-0.

Abstract

Recent studies have suggested that paediatric influenza is a greater medical problem than usually thought because it can cause excess hospitalisations, medical visits, and antibiotic prescriptions even in healthy children, especially those under 2 years. Furthermore, influenza in otherwise healthy children may have substantial socioeconomic consequences for the children and their household contacts. These findings have led many experts to encourage the more widespread use of influenza vaccine in childhood. Although the immunogenicity of the available vaccines is good and they are safe, well-tolerated, and highly effective in preventing influenza and its complications, economic data support universal vaccination only when indirect effectiveness is considered. However, infants aged 6-23 months, children with recurrent acute otitis media or respiratory-tract infections, and healthy children attending day-care centres or elementary schools should be included among the paediatric groups requiring vaccination.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adolescent
  • Antibodies, Viral / blood
  • Child
  • Child, Preschool
  • Clinical Trials as Topic
  • Cost-Benefit Analysis
  • Family Characteristics
  • Hospitalization
  • Humans
  • Infant
  • Infant, Newborn
  • Influenza Vaccines / administration & dosage*
  • Influenza Vaccines / immunology
  • Influenza, Human / complications
  • Influenza, Human / immunology
  • Influenza, Human / prevention & control*
  • Orthomyxoviridae / immunology
  • Otitis Media / etiology
  • Otitis Media / prevention & control
  • Pediatrics*
  • Risk Factors
  • Socioeconomic Factors
  • Vaccination* / economics
  • Vaccination* / statistics & numerical data
  • Vaccines, Attenuated / administration & dosage
  • Vaccines, Attenuated / immunology

Substances

  • Antibodies, Viral
  • Influenza Vaccines
  • Vaccines, Attenuated