Abstract
We previously identified and characterized a novel p53-regulated gene in mouse prostate cancer cells that was homologous to a human gene that had been identified in brain cancers and termed RTVP-1 or GLIPR. In this report, we document that the human RTVP-1 gene is also regulated by p53 and induces apoptosis in human prostate cancer cell lines. We show that the expression of the human RTVP-1 gene is down-regulated in human prostate cancer specimens compared with normal human prostate tissue at the mRNA and protein levels. We further document epigenetic changes consistent with RTVP-1 being a tumor suppressor in human prostate cancer.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Apoptosis / genetics
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Binding Sites
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Cell Division / genetics
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Cell Line, Tumor
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DNA Methylation
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Down-Regulation
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Gene Expression Regulation, Neoplastic
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Gene Silencing
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Genes, Tumor Suppressor
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Humans
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Loss of Heterozygosity
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Male
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Membrane Proteins
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Neoplasm Proteins / genetics*
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Neoplasm Proteins / metabolism
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Nerve Tissue Proteins / genetics*
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Nerve Tissue Proteins / metabolism
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Prostatic Neoplasms / genetics*
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Prostatic Neoplasms / metabolism
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Prostatic Neoplasms / pathology
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Tumor Suppressor Protein p53 / genetics
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Tumor Suppressor Protein p53 / metabolism
Substances
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GLIPR1 protein, human
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Membrane Proteins
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Neoplasm Proteins
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Nerve Tissue Proteins
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Tumor Suppressor Protein p53