Ru(III)-catalyzed cyclization of arene-alkene substrates via intramolecular electrophilic hydroarylation

So Won Youn; Stefan J Pastine; Dalibor Sames

doi:10.1021/ol036385i

Ru(III)-catalyzed cyclization of arene-alkene substrates via intramolecular electrophilic hydroarylation

Org Lett. 2004 Feb 19;6(4):581-4. doi: 10.1021/ol036385i.

Authors

So Won Youn¹, Stefan J Pastine, Dalibor Sames

Affiliation

¹ Department of Chemistry, Columbia University, New York, New York 10027, USA.

PMID: 14961628
DOI: 10.1021/ol036385i

Abstract

[reaction: see text] We herein report that RuCl(3)/AgOTf has proven to be a hydroarylation catalyst with an efficiency and scope superior to previously known methods. This catalyst demonstrated consistent performance with arene-ene substrates of diverse structural features, providing good to excellent yields of cyclization products (chromanes, tetralins, terpenoids, dihydrocoumarins).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkenes / chemical synthesis*
Catalysis
Chromans / chemical synthesis*
Coumarins / chemical synthesis*
Cyclization
Indicators and Reagents
Ruthenium / chemistry*
Terpenes / chemical synthesis*
Tetrahydronaphthalenes / chemical synthesis*

Substances

Alkenes
Chromans
Coumarins
Indicators and Reagents
Terpenes
Tetrahydronaphthalenes
Ruthenium
tetralin