N-Amination of pyrrole and indole heterocycles with monochloramine (NH2Cl)

J Org Chem. 2004 Feb 20;69(4):1368-71. doi: 10.1021/jo035587p.

Abstract

A survey of several electrophilic ammonia reagents for the N-amination of indole- and pyrrole-containing heterocycles revealed that monochloramine (NH(2)Cl) is an excellent reagent for this transformation. Pyrroles and indoles containing a variety of substitution were aminated on nitrogen with isolated yields ranging from 45% to 97%.

MeSH terms

  • Amination
  • Chloramines / chemistry*
  • Heterocyclic Compounds / chemistry*
  • Indoles / chemistry*
  • Molecular Structure
  • Pyrroles / chemistry*

Substances

  • Chloramines
  • Heterocyclic Compounds
  • Indoles
  • Pyrroles